Ginger Extract

Ginger Extract – Bioactive Zingiberaceae Phytocomplex for Anti-inflammatory and Gastroprotective Support

Ginger Extract, obtained from the rhizome of Zingiber officinale, is a phytochemical-rich botanical known for its potent anti-inflammatory, antioxidant, antiemetic, and digestive-enhancing properties. The extract contains a complex profile of biologically active compounds, including gingerols, shogaols, zingerone, and paradols, with [6]-gingerol and [6]-shogaol being the primary contributors to its pharmacological actions.

Biochemically, gingerols and shogaols inhibit key pro-inflammatory mediators such as cyclooxygenase (COX-1 and COX-2) and lipoxygenase (5-LOX) enzymes, thereby reducing the synthesis of prostaglandins and leukotrienes. This mechanism underpins its use in managing inflammatory disorders, including arthritis, muscle pain, and gastrointestinal inflammation.

Ginger also modulates gastrointestinal motility and enhances digestive enzyme secretion, making it effective in treating dyspepsia, nausea, and emesis. Additionally, its antioxidant constituents help neutralize reactive oxygen species (ROS) and upregulate endogenous enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), supporting cellular integrity and reducing oxidative stress.

Standardized Ginger Extracts (often 5–10% gingerols) are widely used in nutraceuticals, functional foods, and phytopharmaceuticals for promoting joint health, gastrointestinal balance, and immune modulation.