Garcinia Extract

Garcinia Extract – Hydroxycitric Acid (HCA)-Enriched Botanical for Lipid Metabolism and Appetite Regulation

Garcinia Extract, obtained from the rind of the fruit Garcinia cambogia, is a phytochemical-rich botanical primarily standardized for (-)-hydroxycitric acid (HCA)—a citric acid derivative known for its role in lipid metabolism, appetite suppression, and weight management.

Biochemically, HCA exerts its effects by inhibiting ATP-citrate lyase, a cytosolic enzyme that catalyzes the conversion of citrate to acetyl-CoA, a key substrate in de novo lipogenesis. This enzymatic blockade reduces fatty acid and cholesterol biosynthesis while promoting the diversion of carbohydrates toward glycogen storage, leading to increased satiety signaling through enhanced hepatic glycogen levels.

Additionally, Garcinia Extract influences serotonin availability by modulating uptake in the brain, contributing to reduced appetite and emotional eating. Some studies also suggest HCA improves leptin sensitivity and reduces oxidative stress markers, supporting its broader role in metabolic homeostasis.

Standardized Garcinia Extracts typically contain 50–60% HCA, and are commonly used in nutraceutical, weight management, and functional food formulations aimed at supporting fat metabolism, appetite control, and body composition improvement.