Fenugreek Extract

Fenugreek Extract – Trigonelline and Saponin-Rich Botanical for Metabolic and Hormonal Modulation

Fenugreek Extract, derived from the seeds of Trigonella foenum-graecum, is a bioactive botanical standardized for key constituents such as trigonelline, 4-hydroxyisoleucine, diosgenin, and furostanolic saponins. It exhibits a broad spectrum of biochemical activities, including glycemic control, lipid regulation, hormonal balance, and digestive support.

Biochemically, 4-hydroxyisoleucine acts as an insulinotropic amino acid, enhancing glucose-dependent insulin secretion and improving insulin sensitivity, making Fenugreek Extract beneficial in the management of type 2 diabetes and metabolic syndrome. Additionally, trigonelline, a methylated alkaloid, contributes antioxidant and neuroprotective effects by modulating NAD⁺-dependent pathways and combating oxidative stress.

The extract’s saponins, particularly diosgenin, exhibit structural similarity to steroidal compounds and are known to support testosterone modulation and libido enhancement, making Fenugreek a popular ingredient in male vitality and sports nutrition formulations. Fenugreek also aids appetite regulation, lactation support, and cholesterol reduction through its fiber content and bile acid-binding capacity.

Standardized Fenugreek Extract (often 50% saponins or 20–40% galactomannan) is widely utilized in nutraceuticals, functional foods, and phytopharmaceuticals focused on metabolic health, hormonal function, and digestive wellness.