Coleus Extract

Coleus Extract – cAMP-Modulating Phytocompound for Metabolic and Cardiovascular Support

Coleus Extract, derived from the roots of Coleus forskohlii, is a botanical extract standardized for forskolin, a labdane diterpenoid known for its potent adenylate cyclase activation properties. This unique mechanism enhances intracellular levels of cyclic adenosine monophosphate (cAMP), a critical second messenger involved in regulating metabolic, cardiovascular, and cellular signaling pathways.

Biochemically, forskolin directly activates adenylate cyclase independent of G-protein coupling, leading to elevated cAMP levels. This cascade results in enhanced lipolysis, thyroid hormone secretion, vasodilation, and cardiac contractility, supporting its use in weight management, respiratory health, and cardiovascular function. Increased cAMP also influences neurotransmitter release and smooth muscle relaxation, contributing to potential applications in asthma and glaucoma therapies.

Coleus Extract exhibits additional antioxidant and anti-inflammatory effects, modulating key mediators such as protein kinase A (PKA) and downstream effectors that regulate cellular metabolism and immune responses.

Standardized Coleus Extract, typically containing 10–20% forskolin, is widely used in nutraceutical, phytopharmaceutical, and sports nutrition products targeting fat metabolism, energy regulation, and vascular health.