Cissus Extract

Cissus Extract – Multifunctional Phytocomplex for Bone, Joint, and Metabolic Support

Cissus Extract, derived from the stem and leaves of Cissus quadrangularis, is a medicinal botanical rich in ketosteroids, flavonoids, triterpenoids, vitamin C, and stilbene derivatives. Traditionally used in Ayurveda for bone healing, this extract exhibits anabolic, anti-inflammatory, antioxidant, and anti-obesity properties, making it valuable in orthopedic and metabolic applications.

Biochemically, Cissus modulates the expression of genes involved in bone matrix formation, including osteocalcin and alkaline phosphatase, while promoting osteoblast proliferation and inhibiting osteoclast activity—supporting bone mineralization and fracture healing. Its ketosteroids are believed to stimulate collagen synthesis, enhancing the structural integrity of connective tissues, tendons, and ligaments.

Cissus Extract also exhibits anti-inflammatory effects via downregulation of COX-2 and TNF-α, aiding in the management of joint pain and inflammatory conditions such as arthritis. In metabolic regulation, it influences adipogenesis, lipid metabolism, and insulin sensitivity, showing promise in managing obesity and metabolic syndrome.

Standardized Cissus Extracts (often with 2.5%–10% ketosteroids) are widely used in nutraceuticals, sports supplements, and bone and joint health formulations, supporting recovery, skeletal integrity, and weight management.