Centella Asiatica Extract

Centella Asiatica Extract – Neuroregenerative and Dermoprotective Triterpenoid Complex

Centella Asiatica Extract, derived from the aerial parts of Centella asiatica, is a pharmacologically active botanical rich in triterpenoid saponins, notably asiaticoside, madecassoside, asiatic acid, and madecassic acid. These constituents exhibit potent wound-healing, neuroprotective, angiogenic, and anti-inflammatory effects, making the extract highly valuable in both clinical and cosmetic applications.

Biochemically, Centella Asiatica modulates collagen synthesis and fibroblast proliferation, supporting extracellular matrix remodeling and tissue repair. Its triterpenes upregulate the expression of type I and type III collagen, as well as fibronectin, facilitating enhanced wound closure and skin elasticity. In the central nervous system, Centella acts on BDNF (brain-derived neurotrophic factor) and MAPK pathways, contributing to improved synaptic plasticity, memory retention, and neural regeneration.

Additionally, Centella Asiatica demonstrates anti-inflammatory activity by inhibiting NF-κB activation and suppressing the release of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Its antioxidant properties further contribute to cellular protection and skin barrier enhancement.

Standardized extracts are commonly used in nutraceuticals, cosmeceuticals, dermatological preparations, and nootropic formulations, with consistent triterpenoid content ensuring reliable efficacy and bioactivity.