Giloy Extract

Giloy Extract – Immunomodulatory and Antioxidant Alkaloid Complex from Tinospora cordifolia

Giloy Extract, derived from the stem of Tinospora cordifolia, is a well-documented Ayurvedic botanical known for its potent immunomodulatory, anti-inflammatory, antioxidant, and antipyretic properties. The extract is rich in alkaloids (e.g., tinosporine, magnoflorine), diterpenoid lactones (e.g., tinosporide, cordifolide), glycosides, and polysaccharides, each contributing to its wide-ranging biochemical and therapeutic effects.

Biochemically, Giloy modulates innate and adaptive immunity by enhancing macrophage activation, increasing phagocytic activity, and stimulating the production of cytokines such as IL-2 and interferon-γ (IFN-γ). Its ability to downregulate TNF-α and IL-1β expression via NF-κB pathway inhibition positions it as an effective agent in inflammatory and autoimmune conditions.

Giloy’s antioxidant capacity is attributed to its regulation of glutathione, superoxide dismutase (SOD), and catalase, helping neutralize reactive oxygen species (ROS) and mitigate oxidative stress. Its adaptogenic properties also support metabolic and stress-response pathways, enhancing overall physiological resilience.

Standardized Giloy Extracts are widely used in immunonutrition, phytopharmaceuticals, and functional health formulations, particularly for applications in immune support, fever management, detoxification, and inflammatory disorders.