Black Pepper Extract

Black Pepper Extract – Bioenhancer Rich in Piperine for Enhanced Nutrient Absorption and Metabolic Modulation

Black Pepper Extract, derived from the dried fruits of Piper nigrum, is a potent phytochemical concentrate primarily standardized to piperine, an alkaloid responsible for its characteristic pungency and significant bioenhancing, antioxidant, and anti-inflammatory properties.

Biochemically, piperine modulates drug and nutrient absorption by inhibiting key metabolic enzymes such as cytochrome P450 (CYP3A4) and UDP-glucuronosyltransferase (UGT), as well as influencing P-glycoprotein efflux mechanisms in the intestinal epithelium. This results in enhanced bioavailability of co-administered compounds including curcumin, resveratrol, berberine, vitamins, and various pharmaceuticals.

Piperine also activates transient receptor potential vanilloid type-1 (TRPV1) channels and stimulates the release of digestive enzymes, supporting gastrointestinal health and nutrient assimilation. In addition, its antioxidant properties help mitigate oxidative stress, while its anti-inflammatory activity is linked to downregulation of pro-inflammatory cytokines such as TNF-α and IL-6.

Black Pepper Extract is widely utilized in nutraceuticals, functional foods, and pharmaceutical formulations to improve the efficacy and potency of active ingredients through synergistic bioavailability enhancement.